Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | 3-Amino-6-bromopyrazine-2-carbonitrile | HCID 11052611 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 178513395 | HCID 178513395 | 77% |
Reaction Steps
A mixture of 3-amino-6-bromo-pyrazine-2-carbonitrile (1 g, 5.025 mmol) was dissolved in MeOH (20.00 mL) and cooled to 0° C. Hydroxylamine hydrochloride (349.2 mg, 5.025 mmol) and triethylamine (508.5 mg, 700.4 μL, 5.025 mmol) were added and the reaction allowed to warm to ambient temperature. After 2 hours the resultant precipitate was filtered off and dried (898 mg, 77% Yield). MS (ES+) 234.89
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09365557B2 |
|---|
| Source dataset | uspto-grants-2016_06 |
|---|
| ORD ID | ord-50b27e619ac3469a80114ba77d3c0317 |
|---|
| Source note | uspto-grants-2016_06 |
|---|
