Methanol → HCID 59471788, 화합물

HRID 2204827노트

반응식

HRID 2204827 반응식
[NH2:1][C:2]1[C:3]([C:14]([OH:16])=[O:15])=[N:4][C:5]([C:8]2[CH:9]=[N:10][CH:11]=[CH:12][CH:13]=2)=[CH:6][N:7]=1.OS(O)(=O)=O.[CH3:22]O>>[NH2:1][C:2]1[C:3]([C:14]([O:16][CH3:22])=[O:15])=[N:4][C:5]([C:8]2[CH:9]=[N:10][CH:11]=[CH:12][CH:13]=2)=[CH:6][N:7]=1

참가 물질

4

반응물 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 594721543-Amino-6-(pyridin-3-yl)pyrazine-2-carboxylic acid

생성물 1

HCID 59471788HCID 59471788, 화합물수율 97%

실험 절차

To 3-amino-6-(3-pyridyl)pyrazine-2-carboxylic acid (2 g, 9.251 mmol) in MeOH (50 mL) was added conc. H2SO4 (907.3 mg, 493.1 μL, 9.251 mmol) and the mixture heated to reflux for 2 hours. The solvent was removed under vacuum and the mixture neutralised with aqueous Na2CO3 and the resulting solid collected by filtration and dried to give the desired product (2.08 g, 97% Yield). MS (ES+) 231.87

후처리

  1. temperaturethe mixture heated
  2. temperatureto reflux for 2 hours
  3. customThe solvent was removed under vacuum
  4. filtrationthe resulting solid collected by filtration
  5. customdried

출처 및 근거

ORD 기록
ord-f0209112058d472d8ab785d12a3d764b
출처 데이터셋
uspto-grants-2016_06
특허 번호
US09365557B2

반응 노트

불러오는 중…