Potassium Iodide → HCID 71272593, compound

Participants

Reaction Conditions

Reaction Steps

25.0 g (188 mmol) of (4-hydroxyphenyl)acetonitrile and 56.6 g (225 mmol) of 11-bromoundecan-1-ol are dissolved in 250 mL of N,N-dimethylformamide. 51.8 g (375 mmol) of potassium carbonate and 6.0 g (36 mmol) of potassium iodide are added and the suspension was heated to 80° C. After 48 h, the reaction mixture is cooled to room temperature and poured to icy water. The precipitate is filtered off, purified on column chromatography (AcOET/Tol: 2/8) and dried overnight at 40° C. 29.8 g of {4-[(11-hydroxyundecyl)oxy]phenyl}acetonitrile are obtained as a slightly yellow solid (52% yield). This material proves chromatographically homogenous and displays spectral characteristics consistent with its assigned structure.

Provenance & Evidence