2,3-Dihydro-1,4-benzodioxin-6-carbaldehyde → HCID 86725132, compound

HRID 2204914Notes

Reaction equation

HRID 2204914 reaction equation
[OH:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][O:13][C:14]1[CH:19]=[CH:18][C:17]([CH2:20][C:21]#[N:22])=[CH:16][C:15]=1[O:23][CH3:24].[O:25]1[C:30]2[CH:31]=[CH:32][C:33]([CH:35]=O)=[CH:34][C:29]=2[O:28][CH2:27][CH2:26]1>>[O:25]1[C:30]2[CH:31]=[CH:32][C:33](/[CH:35]=[C:20](/[C:17]3[CH:18]=[CH:19][C:14]([O:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][OH:1])=[C:15]([O:23][CH3:24])[CH:16]=3)\[C:21]#[N:22])=[CH:34][C:29]=2[O:28][CH2:27][CH2:26]1

Participants

3

Reactant 2

HCID 2481272,3-Dihydro-1,4-benzodioxin-6-carbaldehydeHCID 71272057HCID 71272057, compound

Product 1

HCID 86725132HCID 86725132, compoundYield 80%

Procedure

(2Z)-3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-{4-[(11-hydroxyundecyl)oxy]-3-methoxyphenyl}prop-2-enenitrile is prepared starting from {4-[(11-hydroxyundecyl)oxy]-3-methoxyphenyl}acetonitrile and commercial 1,4-Benzodioxan-6-carboxaldehyde according the same procedure following for example 1 in 80% yield.

Sources & evidence

ORD record
ord-e289b9690f804d5cbdaa13604a38c950
Source dataset
uspto-grants-2016_06
Patent number
US09366906B2

Reaction notes

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