3,4-Dimethoxybenzeneacetonitrile → HCID 71272542, compound

HRID 2204920Notes

Reaction equation

HRID 2204920 reaction equation
[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][C:11]=1[O:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][OH:19])[CH:7]=O)[CH3:2].[CH3:20][O:21][C:22]1[CH:23]=[C:24]([CH2:30][C:31]#[N:32])[CH:25]=[CH:26][C:27]=1[O:28][CH3:29]>>[CH3:20][O:21][C:22]1[CH:23]=[C:24](/[C:30](=[CH:7]/[C:6]2[CH:9]=[CH:10][C:11]([O:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][OH:19])=[C:4]([O:3][CH2:1][CH3:2])[CH:5]=2)/[C:31]#[N:32])[CH:25]=[CH:26][C:27]=1[O:28][CH3:29]

Participants

3

Reactant 2

HCID 667273,4-DimethoxybenzeneacetonitrileHCID 86725133HCID 86725133, compound

Product 1

HCID 71272542HCID 71272542, compoundYield 96%

Procedure

(2Z)-2-(3,4-dimethoxyphenyl)-3-{3-ethoxy-4-[(6-hydroxyhexyl)oxy]phenyl}prop-2-enenitrile is prepared starting from 3-ethoxy-4-[(6-hydroxyhexyl)oxy]benzaldehyde and (3,4-dimethoxyphenyl)acetonitrile according the same procedure following for example 10 in 96% yield. This material proves chromatographically homogenous and displays spectral characteristics consistent with its assigned structure.

Sources & evidence

ORD record
ord-d20dea3050de47629cc48264e436fa48
Source dataset
uspto-grants-2016_06
Patent number
US09366906B2

Reaction notes

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