3,4-Dimethoxybenzeneacetonitrile → HCID 71271871, compound

HRID 2204922Notes

Reaction equation

HRID 2204922 reaction equation
[OH:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][O:8][C:9]1[C:16]([O:17][CH3:18])=[CH:15][C:12]([CH:13]=O)=[CH:11][C:10]=1[O:19][CH3:20].[CH3:21][O:22][C:23]1[CH:24]=[C:25]([CH2:31][C:32]#[N:33])[CH:26]=[CH:27][C:28]=1[O:29][CH3:30]>>[CH3:21][O:22][C:23]1[CH:24]=[C:25](/[C:31](=[CH:13]/[C:12]2[CH:15]=[C:16]([O:17][CH3:18])[C:9]([O:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][OH:1])=[C:10]([O:19][CH3:20])[CH:11]=2)/[C:32]#[N:33])[CH:26]=[CH:27][C:28]=1[O:29][CH3:30]

Participants

3

Reactant 2

HCID 667273,4-DimethoxybenzeneacetonitrileHCID 11323520HCID 11323520, compound

Product 1

HCID 71271871HCID 71271871, compoundYield 97%

Procedure

(2Z)-2-(3,4-dimethoxyphenyl)-3-{4-[(6-hydroxyhexyl)oxy]-3,5-dimethoxyphenyl}prop-2-enenitrile is prepared starting from 4-[(6-hydroxyhexyl)oxy]-3,5-dimethoxybenzaldehyde and (3,4-dimethoxyphenyl)acetonitrile according the same procedure following for example 10 in 97% yield. This material proves chromatographically homogenous and displays spectral characteristics consistent with its assigned structure.

Sources & evidence

ORD record
ord-bf80b3c11da54900b3f9e6bd59d5a0eb
Source dataset
uspto-grants-2016_06
Patent number
US09366906B2

Reaction notes

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