Silane, tris(1-methylethyl)- → HCID 53476668, compound

Participants

Reaction Steps

(22R,26R)-4,22-diamino-5,21-dioxo-1,1,1-triphenyl-10,13,16-trioxa-2,24-dithia-6,20-diazaheptacosane-26,27-diyl didodecanoate was stirred in TFA (0.1 M) containing 5% triisopropylsilane at room temperature for 4 hours. The reaction was concentrated and purified by flash chromatography on an ISCO COMBIFLASH® system using a 0-20% MeOH/DCM gradient (20R,24R)-2,20-diamino-1-mercapto-3,19-dioxo-8,11,14-trioxa-22-thia-4,18-diazapentacosane-24,25-diyl didodecanoate. 1H NMR (DMSO d-6): δ 8.51 (t, 1H), 8.49 (t, 1H), 5.12 (m, 1H), 4.26-4.32 (dd, 1H), 4.08-4.12 (m, 1H), 3.86 (q, 2H), 3.46-3.52 (m, 8H), 3.40 (t, 4H), 3.35 (br s, 4H), 3.12-3.25 (m, 4H), 2.82-2.94 (m, 6H), 2.72-2.79 (dd, 1H), 2.29-2.34 (q, 4H), 1.68-1.72 (q, 4H), 1.49-1.52 (m, 4H), 1.21-1.34 (m, 32H), 0.86 (t, 6H). LRMS [M+H]=866.3.

Provenance & Evidence