HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2205006Generated: November 3, 2026
Sodium Azide → Azido-PEG3-phosphonic acid ethyl ester
https://huagongshe.com/reaction/2205006
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | Diethyl 2-(2-(2-(2-iodoethoxy)ethoxy)ethoxy)ethylphosphonate | HCID 86678292 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Azido-PEG3-phosphonic acid ethyl ester | HCID 86678293 | — |
Reaction Steps
To a solution of diethyl 2-(2-(2-(2-iodoethoxy)ethoxy)ethoxy)ethylphosphonate (1 eq) in DMF (0.5 M) was added sodium azide (3 eq). The reaction mixture was heated at 50° C. overnight. The mixture was then concentrated en vaccuo. The crude material was purified by flash chromatography on a COMBIFLASH® system (ISCO) using 0-5% MeOH/DCM to give the product as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09365506B2 |
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| Source dataset | uspto-grants-2016_06 |
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| ORD ID | ord-18a5ee138ec146c285e68bf8dc9ace8f |
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| Source note | uspto-grants-2016_06 |
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