Toluene → HCID 86678299, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of diethyl(4-((R)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-((R)-2,3-bis(dodecanoyloxy)propylthio)propanamido)-1,1-difluorobutylphosphonate (1 eq) was added 20% piperidine (50 eq) in acetonitrile. The resulting mixture was stirred at 25° C. until the deprotection completed. To the mixture was added toluene and then concentrated en vaccuo. The crude mixture was purified by flash chromatography on a COMBIFLASH® system (ISCO) using 100% EtOAc then 0-10% MeOH/DCM to give the product as a colorless oil.

Provenance & Evidence