1,2-Dichloroethane → HCID 68595010, compound

Participants

Reaction Steps

Dissolve 3′-(4-fluoro-phenyl)-3,4,5,6-tetrahydro-2H-[1,2′]bipyrazinyl (0.320 g, 1.24 mmol) in DCE (5 mL). Add 1-(2-hydroxy-ethyl)-1H-pyrazole-4-carbaldehyde (0.243 g, 1.73 mmol), and stir at room temperature. Add sodium triacetoxyborohydride (0.394 g, 1.86 mmol) and stir at room temperature for 18 hr. Purify via SCX chromatography, followed by silica gel chromatography, eluting with 20:80 then 0:100 hexanes:ethyl acetate then 5:95 methanol:ethyl acetate then 10:90 methanol:ethyl acetate, to give the free base of the title compound (296 mg, 62%). Dissolve the free base (0.290 g, 0.760 mmol) in acetonitrile and add 1N aqueous HCl solution (913 μL, 0.913 mmol) and shake at ambient temperature for 30 min. Freeze and lyophilize to give the title compound (315 mg, 99%). MS (ES): m/z=383 [M+H]+.

Provenance & Evidence