HCID 178418361, compound → HCID 178441243, compound

HRID 22051Notes

Reaction equation

HRID 22051 reaction equation
[CH2:1]([C:5]1[N:9]2[CH:10]([C:16]3[CH:21]=[CH:20][C:19]([C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=4[C:28]4[NH:32][N:31]=[N:30][N:29]=4)=[CH:18][CH:17]=3)[CH2:11][CH2:12][C:13](=[N:14]O)[C:8]2=[N:7][CH:6]=1)[CH2:2][CH2:3][CH3:4].[H][H]>[Pd].CO>[CH2:1]([C:5]1[N:9]2[CH:10]([C:16]3[CH:17]=[CH:18][C:19]([C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=4[C:28]4[NH:32][N:31]=[N:30][N:29]=4)=[CH:20][CH:21]=3)[CH2:11][CH2:12][CH:13]([NH2:14])[C:8]2=[N:7][CH:6]=1)[CH2:2][CH2:3][CH3:4]

Participants

5

Reactant 2

HCID 178418361HCID 178418361, compoundHCID 178441244HCID 178441244, compound

Product 1

HCID 178441243HCID 178441243, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Alternatively, the title compound of Example 1451 can be prepared from the corresponding oxime. A suspension of the biphenyl imidazolyl oxime (0.059 mmol, the title compound of Example 1449) and 20 mg (0.0188 mmol) of 10% palladium on charcoal in 1.5 mL of methanol is stirred at room temperature under 50 psi of hydrogen gas until the reaction is complete. The mixture is filtered through a pad of celite, concentrated in vacuo and purified to give the title compound of Example 1451.

Workup

  1. filtrationThe mixture is filtered through a pad of celite
  2. concentrationconcentrated in vacuo
  3. custompurified

Sources & evidence

ORD record
ord-692fdb2f469d43c3bdee7f7f66134e3f
Source dataset
uspto-grants-1995_06
Patent number
US05426105

Reaction notes

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