Potassium Phosphate, Tribasic → HCID 86718102, compound

Participants

Reaction Steps

A suspension of methyl 3-chloro-2-phenylquinoxaline-6-carboxylate (100 mg, 0.33 mmol, 1.00 equiv), 4-(trifluoromethyl)phenylboronic acid (69.9 mg, 0.37 mmol, 1.10 equiv), K3PO4 (142 mg, 0.67 mmol, 2.00 equiv), Pd(PPh3)4 (11 mg, 0.01 mmol, 0.03 equiv) in toluene (1 mL) was placed in a 10-mL sealed tube under an inert atmosphere allowed to react, with stifling, overnight at 100° C. in an oil bath. The reaction was quenched by the addition of 20 mL of water, and the solids were collected by filtration, resulting in 80 mg (59%) of methyl 2-phenyl-3-(4-(trifluoromethyl)phenyl)quinoxaline-6-carboxylate as a yellow solid.

Provenance & Evidence