HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Acetamido-2-hydroxy-5-nitrobenzoic acid → 4-Amino-2-hydroxy-5-nitrobenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Acetamido-2-hydroxy-5-nitrobenzoic acid | HCID 67287438 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | 4-Amino-2-hydroxy-5-nitrobenzoic acid | HCID 21842191 | 82.5% |
Reaction Steps
A mixture of 4-acetamido-2-hydroxy-5-nitrobenzoic acid (5 g, 20.8 mmol, 1.00 equiv) and HCl (aq.) (110 mL, 6N) in a 500-mL round-bottom flask was allowed to react, with stifling, for 2 hrs while the temperature was maintained at reflux. The mixture was cooled. The solids were collected by filtration, yielding 3.4 g (82%) of 4-amino-2-hydroxy-5-nitrobenzoic acid as a brown solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09370522B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-68bb80ab28f04793bc107359e15c65fb |
| Source note | uspto-grants-2016_06 |