4-(Hydroxymethyl)benzeneboronic acid → HCID 86718120, compound

Participants

Reaction Steps

The product was obtained via a Suzuki coupling reaction using the method previously shown in Example 20, Step 3, using methyl 3-bromo-2-phenylquinoxaline-6-carboxylate (100 mg, 0.29 mmol, 1.00 equiv) and 4-(hydroxymethyl)phenylboronic acid (66.12 mg, 0.43 mmol, 1.50 equiv) as reactants. Purification via silica gel column (dichloromethane/methanol (10:1)) afforded 80 mg (76%) of 3-(4-(hydroxymethyl)phenyl)-2-phenylquinoxaline-6-carboxylic acid as a light yellow solid.

Provenance & Evidence