4-(Trifluoromethoxy)phenylboronic acid → HCID 86718122, compound

Participants

Reaction Steps

The product was obtained via a Suzuki coupling reaction using the method previously shown in Example 20, Step 3, using methyl 3-bromo-2-phenylquinoxaline-6-carboxylate (100 mg, 0.29 mmol, 1.00 equiv) and 4-(trifluoromethoxy)phenylboronic acid (89.6 mg, 0.43 mmol, 1.50 equiv) as reactants. Purification via silica gel column (dichloromethane/methanol (10:1)) yielded 57 mg (47%) of 2-phenyl-3-(4-(trifluoromethoxy)phenyl)quinoxaline-6-carboxylic acid as a white solid.

Provenance & Evidence