3-(Trifluoromethoxy)phenylboronic Acid (contains varying amounts of Anhydride) → HCID 86718123, compound

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Reaction Steps

The product was obtained via a Suzuki coupling reaction using the method previously shown in Example 20, Step 3, using methyl 3-bromo-2-phenylquinoxaline-6-carboxylate (100 mg, 0.29 mmol, 1.00 equiv) and 3-(trifluoromethoxy)phenylboronic acid (89.6 mg, 0.43 mmol, 1.50 equiv) as reactants. Purification via silica gel column (dichloromethane/methanol (10:1)) afforded 67 mg (55%) of 2-phenyl-3-(3-(trifluoromethoxy)phenyl)quinoxaline-6-carboxylic acid as a white solid.

Provenance & Evidence