4,4,5,5-Tetramethyl-2-(4-nitrophenyl)-1,3,2-dioxaborolane → HCID 86718125, compound

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Reaction Steps

The product was obtained via a Suzuki coupling reaction using the method previously shown in Example 20, Step 3, using methyl 3-bromo-2-phenylquinoxaline-6-carboxylate (100 mg, 0.29 mmol, 1.00 equiv) and 4,4,5,5-tetramethyl-2-(4-nitrophenyl)-1,3,2-dioxaborolane (144.4 mg, 0.58 mmol, 2.00 equiv) as reactants. Purification via silica gel column (dichloromethane/methanol (10:1)) afforded 27 mg (24%) of 3-(4-nitrophenyl)-2-phenylquinoxaline-6-carboxylic acid as a yellow solid.

Provenance & Evidence