2-Dicyclohexylphosphino-2',4',6'-triisoprophylbiphenyl → HCID 86718131, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of methyl 3-bromo-2-phenylquinoxaline-6-carboxylate (100 mg, 0.29 mmol, 1.00 equiv), X-phos (14 mg, 0.03 mmol, 0.10 equiv), Pd2(dba)3 (27 mg, 0.03 mmol, 0.10 equiv) in THF (10 mL), and Et2Zn in THF (5.8 mL, 20.00 equiv, 1M was allowed to react, with stifling, overnight while the temperature was maintained at 80° C. in an oil bath. The reaction was quenched by the addition of 2 mL of water. The resulting mixture was concentrated under vacuum and purified by prep-TLC (petroleum ether:ethyl acetate (4:1)) yielding 50 mg (35%) of methyl 3-ethyl-2-phenylquinoxaline-6-carboxylate as a yellow solid.

Provenance & Evidence