Morpholine → HCID 70654224, compound

HRID 2205159Notes

Reaction equation

HRID 2205159 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:18]([C:19]3[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][CH:20]=3)=[N:17][C:16]3[C:11](=[CH:12][CH:13]=[C:14]([S:27](O)(=[O:29])=[O:28])[CH:15]=3)[N:10]=2)=[CH:5][CH:4]=1.[NH:31]1[CH2:36][CH2:35][O:34][CH2:33][CH2:32]1>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[C:18]([C:19]3[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][CH:20]=3)=[N:17][C:16]3[C:11](=[CH:12][CH:13]=[C:14]([S:27]([N:31]4[CH2:36][CH2:35][O:34][CH2:33][CH2:32]4)(=[O:28])=[O:29])[CH:15]=3)[N:10]=2)=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 86670229HCID 86670229, compound

Product 1

HCID 70654224HCID 70654224, compoundYield 34%

Procedure

The product was obtained using the same synthetic methods as Example 54, using 2,3-bis(4-methoxyphenyl)quinoxaline-6-sulfonic acid (350 mg, 0.83 mmol, 1.00 equiv) and morpholine (1.44 g, 16.53 mmol, 20.00 equiv) as reactants. Purification by Prep-HPLC afforded 60 mg (34%) of 2,3-bis(4-methoxyphenyl)-6-(morpholinosulfonyl)quinoxaline as a white solid.

Workup

  1. customThe product was obtained
  2. customPurification by Prep-HPLC

Sources & evidence

ORD record
ord-2afb80d8a1894f3193f31a5f372d1d13
Source dataset
uspto-grants-2016_06
Patent number
US09370522B2

Reaction notes

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