Sodium Hydroxide → HCID 86718146, compound

Participants

Reaction Steps

A solution of (E)-methyl 3-(2,3-bis(4-methoxyphenyl)quinoxalin-6-yl)acrylate (150 mg, 0.35 mmol, 1.00 equiv) and sodium hydroxide (70.4 mg, 1.76 mmol, 5.00 equiv) in methanol (10 mL) and H2O (2 ml) was stirred for 2 h at 50° C. in an oil bath. The resulting mixture was concentrated under vacuum, diluted with 20 mL of water. The pH value of the solution was adjusted to 3 with 1N hydrochloric acid. The solids were collected by filtration, and purified by re-crystallization from methanol, affording 80 mg (55%) of (E)-3-(2,3-bis(4-methoxyphenyl)quinoxalin-6-yl)acrylic acid as a yellow solid.

Provenance & Evidence