Methanol → HCID 86718151, compound

Participants

Reaction Conditions

Reaction Steps

Methyl 2-(4-methoxyphenyl)-3-phenylquinoline-7-carboxylate (40 mg, 0.11 mmol, 1.00 equiv), LiOH (13 mg, 0.54 mmol, 5.00 equiv), methanol (5 mL), and water (0.5 mL) were placed in a 50-mL round-bottom flask and stirred for 5 hr at 50° C. in an oil bath. The resulting mixture was concentrated under vacuum, diluted with 10 mL of H2O, and the pH adjusted to 4-5 with 1N HCl. The resulting solids were collected by filtration and dried in an oven under reduced pressure, yielding 23 mg (59%) of 2-(4-methoxyphenyl)-3-phenylquinoline-7-carboxylic acid as a yellow solid.

Provenance & Evidence