HCID 137010196, compound → HCID 137010190, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of compound 22 (0.22 g, 0.42 mmol) in methanol (30 mL) was added HCO2NH4 (600 mg, 9.52 mmol), followed by Pd(OH)2/C (500 mg). The reaction mixture was stirred at 80° C. for 15 h, then cooled to 25° C., filtered and then evaporated to dryness under reduced pressure. Purification by silica gel chromatography [dichloromethane:methanol (20:1 to 5:1)] and prep-HPLC provided the product 23 (0.046 g, 33%) as a white solid. LC-MS (M+H)+=334.1

Provenance & Evidence