Methanol → HCID 118294404, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of compound 25 (0.225 g, 0.35 mmol) in NH3.MeOH (40 mL) was stirred in a sealed tube at 65° C. for 16 hrs, warmed to 25° C. and stirred for 3 hrs. TLC showed the reaction was completed, the reaction solution was concentrated and the crude compound was purified by silica gel chromatography column [dichloromethan:methanol (30:1)] to give product 26 as an colorless oil (0.16 g, 92%).

Provenance & Evidence