反应详情

温度

20 °C

Ac2O (0.5 mL) was added into a solution of compound 34 (0.114 g, 0.24 mmol) in dry pyridine (4 mL). The reaction mixture was stirred at 20° C. for 3 h and then quenched by saturated aqueous NaHCO3 solution (2 mL). The organic phase was extracted with dichloromethane and then evaporated to dryness under reduced pressure. Purification by silica gel chromatography [petroleum ether:ethyl acetate (4:1)] afforded 35 (0.12 g, 88%) as a white solid. LC-MS: (M+H)+=517.2

1. customquenched by saturated aqueous NaHCO3 solution (2 mL)
2. extractionThe organic phase was extracted with dichloromethane
3. customevaporated to dryness under reduced pressure
4. customPurification by silica gel chromatography [petroleum ether:ethyl acetate (4:1)]