HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroacetone → 6-Chloro-2-methylimidazo(1,2-b)pyridazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroacetone | HCID 6571 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 6-Amino-3-chloropyridazine | HCID 21643 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 6-Chloro-2-methylimidazo(1,2-b)pyridazine | HCID 10442072 | 80.1% |
Reaction Conditions
| Temperature | 150 °C |
|---|
Reaction Steps
To a solution of 6-chloropyridazin-3-amine (2.35 g, 18.1 mmol, 1.0 equiv) in ethanol (15 mL) was added 1-chloropropan-2-one (2.92 mL, 36.3 mmol, 2.0 equiv) and triethylamine (2.53 mL, 18.1 mmol, 1.0 equiv). The solution was heated at 150° C. for 30 min then quenched with water. Purification by column chromatography using 30% ethyl acetate in hexanes elution gave 2.43 g of the brown solid, 80%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09370515B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-0d9a4f03b8304040ba63a17d87d5f7ab |
| Source note | uspto-grants-2016_06 |