HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid → HCID 90388249, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | Cyclopropylamine | HCID 69828 | — |
| Reactant | 8-Bromo-6-chloroimidazo(1,2-b)pyridazine | HCID 46835269 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 90388249 | HCID 90388249 | 80% |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
To a solution of 8-bromo-6-chloroimidazo[1,2-b]pyridazine (1.00 g, 3.21 mmol, 1.0 equiv) and p-TSA (611 mg, 3.21 mmol, 1.0 equiv) in DMSO (10.0 mL) was added cyclopropylamine (1.13 mL, 16.1 mmol, 5.0 equiv) and heated to 100° C. for 24 h. Purification by column chromatography using 50% ethyl acetate in hexanes elution gave 536 mg of the white solid, 80%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09370515B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-244af766cb9b4ccc966b39a58823707d |
| Source note | uspto-grants-2016_06 |