HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2205207Generated: October 31, 2026
Potassium Carbonate → HCID 90388494, compound
https://huagongshe.com/reaction/2205207
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3,4-Dimethoxyaniline | HCID 22770 | — |
| Reactant | 1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine) | HCID 636044 | — |
| Reactant | HCID 90387861 | HCID 90387861 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 90388494 | HCID 90388494 | 116.8% |
Reaction Steps
To a solution of 6-chloro-3-(7-methylbenzo[b]thiophen-2-yl)imidazo[1,2-b]pyridazine (50 mg, 0.167 mmol, 1.0 equiv), xantphos (19 mg, 0.0334 mmol, 0.2 equiv), palladium acetate (4 mg, 0.0167 mmol, 0.1 equiv), and potassium carbonate (461 mg, 3.34 mmol, 20 equiv) in dioxane (5.0 mL) was added 3,4-dimethoxyaniline (21 mg, 0.184 mmol, 1.1 equiv) and heated to 110° C. for 2 h. Purification by column chromatography using 2% methanol in dichloromethane elution gave 40 mg, 0.195 mmol of the yellow solid, 58%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09370515B2 |
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| Source dataset | uspto-grants-2016_06 |
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| ORD ID | ord-f52c8253cf1e4c4f9eb47c59d0b99bfd |
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| Source note | uspto-grants-2016_06 |
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