HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2205214Generated: November 1, 2026
Potassium Carbonate → HCID 78426687, compound
https://huagongshe.com/reaction/2205214
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3,4-Dimethoxyaniline | HCID 22770 | — |
| Reactant | 1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine) | HCID 636044 | — |
| Reactant | HCID 90387662 | HCID 90387662 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 78426687 | HCID 78426687 | — |
Reaction Steps
To a solution of 6-chloro-3-(4,5,6-trimethoxybenzo[b]thiophen-2-yl)imidazo[1,2-b]pyridazine (50 mg, 0.133 mmol, 1.0 equiv), xantphos (15 mg, 0.0266 mmol, 0.2 equiv), palladium acetate (2 mg, 0.0133 mmol, 0.1 equiv), and potassium carbonate (367 mg, 2.66 mmol, 20 equiv) in dioxane (5.0 mL) was added 3,4-dimethoxyaniline (20 mg, 0.133 mmol, 1.0 equiv) and heated to 110° C. for 2 h. Purification by column chromatography using 2% methanol in dichloromethane elution gave the product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09370515B2 |
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| Source dataset | uspto-grants-2016_06 |
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| ORD ID | ord-36441e35c6cc41d08ff91cd7cc44e50b |
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| Source note | uspto-grants-2016_06 |
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