HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid → HCID 178521579, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | 3-Bromo-6-chloroimidazo(1,2-b)pyridazine | HCID 12872323 | — |
| Reactant | HCID 178511715 | HCID 178511715 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 178521579 | HCID 178521579 | 82.2% |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
To 6-chloro-3-bromoimidazo[1,2-b]pyridazine (1.00 g, 4.30 mmol, 1.0 equiv) and p-TSA (818 mg, 4.30 mmol, 1.0 equiv) in DMSO (7.00 mL) was added trans-4-aminocyclohexanol (1.49 g, 12.9 mmol, 3.0 equiv). The mixture was heated at 100° C. for 24 h. Purification by column chromatography using 5% methanol in dichloromethane elution gave 1.1 g of the yellow solid, 83%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09370515B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-7489922e129a48c7aa8c42cee6484a13 |
| Source note | uspto-grants-2016_06 |