反应详情

To a solution of 5,6-dihydro-5-tosylthieno[3,2-c]pyridin-7(4H)-one (1.24 g, 4.03 mmol, 1.0 equiv) in HOt-Bu (15.0 mL) was added KOt-Bu (904 mg, 8.06 mmol, 2.0 equiv) and heated to reflux for 2 h. The mixture was quenched with water and then extracted with ethyl acetate. Purification by column chromatography using 50% ethyl acetate in hexanes elution gave 1.09 g of white solid, 89%.

1. temperatureheated
2. temperatureto reflux for 2 h
3. customThe mixture was quenched with water
4. extractionextracted with ethyl acetate
5. customPurification by column chromatography
6. wash50% ethyl acetate in hexanes elution