HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tin tetrachloride → (E)-1-ethoxy-10,12-dimethylazacyclododec-9-en-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tin tetrachloride | HCID 24287 | — |
| Reactant | acetaldehyde O-ethyl oxime | HCID 533741 | — |
| Reactant | 2-(Prop-1-en-2-yl)cyclooctanone | HCID 89525642 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | (E)-1-ethoxy-10,12-dimethylazacyclododec-9-en-2-one | HCID 89526188 | 87% |
Reaction Steps
Following the general procedure as described in Example 23, 2-(prop-1-en-2-yl)cyclooctanone (1.50 g, 9.02 mmol), acetaldehyde O-ethyl oxime (1.18 g, 13.53 mmol), and SnCl4 (2.35 g, 9.02 mmol) in 1,2-dichloroethane (90 ml) were reacted to give the title product as a colorless liquid (1.98 g, 87% yield). E isomer>96%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09371262B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-4d123007867f4764897cf564709291dc |
| Source note | uspto-grants-2016_06 |