HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tin tetrachloride → (E)-1-methoxy-14,16-dimethylazacyclohexadec-13-en-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tin tetrachloride | HCID 24287 | — |
| Reactant | Acetaldehyde, O-methyloxime | HCID 535486 | — |
| Reactant | 2-(Prop-1-en-2-yl)cyclododecanone | HCID 13582448 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | (E)-1-methoxy-14,16-dimethylazacyclohexadec-13-en-2-one | HCID 131735808 | 88% |
Reaction Steps
Following the general procedure as described in Example 23, 2-(prop-1-en-2-yl)cyclododecanone (2.00 g, 9.02 mmol), acetaldehyde O-methyl oxime (0.99 g, 13.53 mmol), and SnCl4 (2.35 g, 9.02 mmol) in 1,2-dichloroethane (90 ml) were reacted to give the title product as a colorless liquid (2.33 g, 88% yield). Mixture of E/Z isomers in a ratio of 3:1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09371262B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-9690829cff574137975a50019cc3aa1a |
| Source note | uspto-grants-2016_06 |