Potassium Carbonate → HCID 86729965, compound

Participants

Reaction Steps

Compound 65-b was prepared by stirring 65 (20 mg, 0.043 mmol) in EtOH/H2O (1:1, 4 mL) and K2CO3 (11.9 mg, 0.086 mmol) overnight at room temperature. Reaction mixture was then neutralized to PH 3.0, extracted with EtOAc and then dried over MgSO3 to generate 17 mg of 65-b (90%). 1H NMR (500 MHz, CDCl3) δ 3.20 (s, 3H), 7.05 (d, J=8.8 Hz, 2H), 7.30 (d, J=8.8 Hz, 2H), 7.64 (t, J=7.8 Hz, 1H), 7.70 (d, J=7.9 Hz, 1H), 8.13 (s, 1H), 8.18 (d, J=7.7 Hz, 1H), 8.38 (dd, J=2.2, 8.8 Hz, 1H), 8.43 (d, J=8.7 Hz, 1H), 8.84 (s, 1H), 8.91 (d, J=1.6 Hz, 1H). 13C NMR (126 MHz, CDCl3) δ 38.27, 52.35, 113.18, 122.67, 126.22, 127.84, 129.34, 129.78, 131.40, 131.81, 133.62, 134.77, 137.37, 139.49, 140.02, 150.09, 153.94, 163.93, 165.23. LCQ (M−H+) calcd C20H16ClN3O5S 444. found 444.

Provenance & Evidence