HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-3-(trifluoromethyl)aniline → N4-(4-chloro-3-(trifluoromethyl)phenyl)-7-methoxyquinazoline-4,6-diamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-3-(trifluoromethyl)aniline | HCID 67574 | — |
| Reactant | 4-Chloro-7-methoxy-6-nitroquinazoline | HCID 10490187 | — |
| Reactant | N4-(3-Chloro-4-fluorophenyl)-7-(2-methoxyethoxy)quinazoline-4,6-diamine | HCID 18765584 | — |
| Product | N4-(4-chloro-3-(trifluoromethyl)phenyl)-7-methoxyquinazoline-4,6-diamine | HCID 86727279 | — |
Reaction Steps
Starting material: N4-(4-chloro-3-(trifluoromethyl)phenyl)-7-methoxyquinazoline-4,6-diamine was prepared according to the same method of preparation of N4-(3-chloro-4-fluorophenyl)-7-(2-methoxy)ethoxyquinazoline-4,6-diamine in WO2008/33747, but the starting materials were 4-chloro-7-methoxy-6-nitro-quinazoline and 4-chloro-3-(trifluoromethyl) aniline; other starting materials were prepared as example 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09371292B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-680c07fbdf6d4a81bc3dde1b316efcf3 |
| Source note | uspto-grants-2016_06 |