HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chloro-2,4-difluoroaniline → N4-(3-chloro-2,4-difluorophenyl)-7-methoxyquinazoline-4,6-diamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chloro-2,4-difluoroaniline | HCID 223089 | — |
| Reactant | 4-Chloro-7-methoxy-6-nitroquinazoline | HCID 10490187 | — |
| Reactant | N4-(3-Chloro-4-fluorophenyl)-7-(2-methoxyethoxy)quinazoline-4,6-diamine | HCID 18765584 | — |
| Product | N4-(3-chloro-2,4-difluorophenyl)-7-methoxyquinazoline-4,6-diamine | HCID 66609294 | — |
Reaction Steps
Starting material: N4-(3-chloro-2,4-difluorophenyl)-7-methoxyquinazoline-4,6-diamine was prepared according to the same method of preparation of N4-(3-chloro-4-fluorophenyl)-7-(2-methoxy)ethoxyquinazoline-4,6-diamine in WO2008/33747, but the starting materials were 4-chloro-7-methoxy-6-nitro-quinazoline and 3-chloro-2,4-difluoro-aniline; other starting materials were prepared as example 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09371292B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-534f3b46297a44e99610cad3214a6731 |
| Source note | uspto-grants-2016_06 |