HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromo-3-chloro-2-fluoroaniline → N4-(4-bromo-3-chloro-2-fluorophenyl)-7-methoxyquinazoline-4,6-diamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromo-3-chloro-2-fluoroaniline | HCID 2782705 | — |
| Reactant | 4-Chloro-7-methoxy-6-nitroquinazoline | HCID 10490187 | — |
| Reactant | N4-(3-Chloro-4-fluorophenyl)-7-(2-methoxyethoxy)quinazoline-4,6-diamine | HCID 18765584 | — |
| Product | N4-(4-bromo-3-chloro-2-fluorophenyl)-7-methoxyquinazoline-4,6-diamine | HCID 86727282 | — |
Reaction Steps
Starting material: N4-(4-bromo-3-chloro-2-fluorophenyl)-7-methoxyquinazoline-4,6-diamine was prepared according to the same method of preparation of N4-(3-chloro-4-fluorophenyl)-7-(2-methoxy)ethoxyquinazoline-4,6-diamine in WO2008/33747, but the starting materials were 4-chloro-7-methoxy-6-nitro-quinazoline and 4-bromo-3-chloro-2-fluoro-aniline; other starting materials were prepared as example 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09371292B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-581554cd296d418e85f84b0572a9a4fa |
| Source note | uspto-grants-2016_06 |