1-Benzofuran-2-sulfonyl chloride → N-(5-chloro-2-{[(2-fluoropyridin-3-yl)methyl]thio}phenyl)-1-benzofuran-2-sulfonamide

HRID 2205348Notes

Reaction equation

HRID 2205348 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([S:9][CH2:10][C:11]2[C:12]([F:17])=[N:13][CH:14]=[CH:15][CH:16]=2)=[C:6]([CH:8]=1)[NH2:7].[O:18]1[C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=2[CH:20]=[C:19]1[S:27](Cl)(=[O:29])=[O:28]>N1C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([S:9][CH2:10][C:11]2[C:12]([F:17])=[N:13][CH:14]=[CH:15][CH:16]=2)=[C:6]([NH:7][S:27]([C:19]2[O:18][C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=3[CH:20]=2)(=[O:28])=[O:29])[CH:8]=1

Participants

4

Reactant 2

HCID 27951721-Benzofuran-2-sulfonyl chlorideHCID 679726225-Chloro-2-(((2-fluoropyridin-3-yl)methyl)thio)aniline

Product 1

HCID 67972731N-(5-chloro-2-{[(2-fluoropyridin-3-yl)methyl]thio}phenyl)-1-benzofuran-2-sulfonamideYield 26.9%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Following General Procedure B, the title compound (235 mg) was prepared from 5-chloro-2-(((2-fluoropyridin-3-yl)methyl)thio)aniline (522 mg, 1.948 mmol) and benzofuran-2-sulfonyl chloride (421 mg, 1.948 mmol) in pyridine (5 ml).

Sources & evidence

ORD record
ord-073ea9de1df1403f8d6fbb38448a9b38
Source dataset
uspto-grants-2016_06
Patent number
US09371278B2

Reaction notes

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