HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 5-Chloro-2-((pyrimidin-2-ylmethyl)thio)aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Amino-4-chlorobenzenethiol | HCID 12000 | — |
| Reactant | 2-(Chloromethyl)pyrimidine | HCID 12877371 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5-Chloro-2-((pyrimidin-2-ylmethyl)thio)aniline | HCID 62698810 | 50.8% |
Reaction Steps
Following General Procedure A, the title compound (284 mg, 39%) was prepared from 2-amino-4-chlorobenzenethiol (529 mg, 3.33 mmol), 2-(chloromethyl)pyrimidine (366 mg, 2.22 mmol) and K2CO3 (1.53 g, 11.09 mmol) in DMF (10 ml).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09371278B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-b48caa54b9874cd7ad9923f93b433e28 |
| Source note | uspto-grants-2016_06 |