Benzenesulfonyl chloride → HCID 68597590, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-(3,5-dimethyl-1H-pyrazol-4-ylmethyl)-3′-(4-fluorophenyl)-3,4,5,6-tetrahydro-2H-[1,2′]bipyrazinyl (0.160 g, 0.4 mmol, 1 eq) add benzenesulfonyl chloride (56 μL, 0.4 mmol) followed by pyridine (1 mL). Heat to 120° C. with stirring for 4 hr. Add water and extract 3 times with ethyl acetate (20 mL), dry (magnesium sulfate), concentrate and purify (silica gel chromatography, eluting with 25:75 to 75:25 ethyl acetate:DCM). Lyophilize from a 50% acetonitrile/water solution to give the title compound as a white solid (138 mg, 68%). MS (ES): m/z=507.1 [M+H]+.

Provenance & Evidence