HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 220559Generated: October 26, 2026
2-Bromoethanol → 1-(2-hydroxyethyl)-1H-pyrazole-4-carbaldehyde
https://huagongshe.com/reaction/220559
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Bromoethanol | HCID 10898 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1H-pyrazole-4-carbaldehyde | HCID 5130673 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 1-(2-hydroxyethyl)-1H-pyrazole-4-carbaldehyde | HCID 24702608 | 97% |
Reaction Steps
Combine 1H-pyrazole-4-carbaldehyde (0.110 g, 1.14 mmol), 2-bromoethanol (0.172 g, 1.37 mmol), and potassium carbonate (0.236 g, 1.71 mmol) in acetonitrile (2 mL). Heat in microwave at 150° C. for 20 min. Cool to room temperature and filter, washing with acetonitrile. Concentrate filtrate to give 1-(2-hydroxy-ethyl)-1H-pyrazole-4-carbaldehyde (0.155 g, 97%). GC-MS: m/z=140 [M+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08202873B2 |
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| Source dataset | uspto-grants-2012_06 |
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| ORD ID | ord-547bb23721c8469ead658c86e338b32b |
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| Source note | uspto-grants-2012_06 |
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