3-Hydroxypiperidine → 1-(5-((S)-1-Aminoethyl)-1-methyl-1H-pyrrolo[3,2-b]pyridin-6-yl)piperidin-3-ol

Participants

Reaction Conditions

Reaction Steps

A mixture of (S)-1-(6-bromo-1-methyl-1H-pyrrolo[3,2-b]pyridin-5-yl)ethan-1-amine (508 mg, 2.00 mmol), piperidin-3-ol (1.01 g, 10.0 mmol) and potassium 2-methylpropan-2-olate (1.56 g, 14.0 mmol) in dioxane (15 mL) was heated to 150° C. for 2 hours in a microwave reactor. The solvent was evaporated in vacuo to give the crude product (1.5 g) as a yellow oil which was used in the next step without further purification. ESI-MS m/z [M+H]+ calc'd for C15H22N4O, 275. found 275.

Provenance & Evidence