HRID2205613

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)N1CC=C(B2OC(C)(C)C(C)(C)O2)CC1

HCID4642098

tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydropyridine-1(2H)-carboxylate

C16H28BNO4

结构：C[C@H](NC(=O)OCc1ccccc1)c1nc2ccn(C)c2cc1Br

HCID118214750

未命名化合物

PRODUCTS

生成物

结构：C[C@H](NC(=O)OCc1ccccc1)c1nc2ccn(C)c2cc1C1=CCN(C(=O)OC(C)(C)C)CC1

HCID118214754

未命名化合物

PROCEDURE

实验过程

The title compound was prepared similar to STEP A in PREPARATION 17 using tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydropyridine-1(2H)-carboxylate and benzyl (S)-(1-(6-bromo-1-methyl-1H-pyrrolo[3,2-b]pyridin-5-yl)ethyl)carbamate as starting materials.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1cc7173cd610432d9baf7d608165c2c7
来源数据集: uspto-grants-2016_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09371321B2
来源说明: uspto-grants-2016_06

反应 SMILES

CC1(C)C(C)(C)OB([C:9]2[CH2:10][CH2:11][N:12]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:13][CH:14]=2)O1.Br[C:24]1[CH:25]=[C:26]2[N:45]([CH3:46])[CH:44]=[CH:43][C:27]2=[N:28][C:29]=1[C@@H:30]([NH:32][C:33](=[O:42])[O:34][CH2:35][C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1)[CH3:31]>>[CH2:35]([O:34][C:33]([NH:32][C@H:30]([C:29]1[N:28]=[C:27]2[CH:43]=[CH:44][N:45]([CH3:46])[C:26]2=[CH:25][C:24]=1[C:9]1[CH2:10][CH2:11][N:12]([C:15]([O:17][C:18]([CH3:19])([CH3:20])[CH3:21])=[O:16])[CH2:13][CH:14]=1)[CH3:31])=[O:42])[C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1