Diisopropylethylamine → HCID 118214760, compound

Participants

Reaction Conditions

Reaction Steps

To crude tert-butyl (S)-4-((5-(1-aminoethyl)-1-methyl-1H-pyrrolo[3,2-b]pyridin-6-yl)amino)piperidine-1-carboxylate was added HOAc (2 drops), followed by ACN (2 mL), 2-amino-4-chloro-6-methylpyrimidine-5-carbonitrile (0.083 g, 0.493 mmol), and DIPEA (0.344 mL, 1.970 mmol). The reaction mixture was stirred at 75° C. for 1 hour. LCMS showed the reaction was complete, though messy. The volatiles were removed by N2 flow. The crude title compound was used without further purification. ESI-MS m/z [M+H]+ calc'd for C26H35N9O2, 506. found 506.

Provenance & Evidence