HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → HCID 73057222, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | HCID 90036926 | HCID 90036926 | — |
| Product | HCID 73057222 | HCID 73057222 | — |
Reaction Steps
A solution of 5-methoxy-2-methyl-1H-indol-3-yl)acetic acid (1.3 eq), HOBT (1.3 eq), EDC.HCl (1.3 eq) in DMF (premixed for 3 min) was added to (S)-9-amino-9-(5-(2-methoxyquinolin-3-yl)oxazol-2-yl)nonan-3-one from the previous step (1 eq), followed by DIPEA (1.3 eq). The mixture was stirred at room temperature over night. The product was purified by preparative RP-HPLC, using water (+0.1% TFA) and MeCN (+0.1% TFA) as eluents (C18 column). MS (ES) C34H38N4O5 requires: 582.69, found: 583.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09371295B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-aa5cec155dc04b30981d7e262b5f02d9 |
| Source note | uspto-grants-2016_06 |