HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Hydroxybenzotriazole → HCID 73057225, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 5-Methoxy-2-methylindole-3-acetic acid | HCID 76151 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | HCID 90036254 | HCID 90036254 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 73057225 | HCID 73057225 | — |
Reaction Steps
(S)-9-amino-9-(5-(2-methoxyquinolin-3-yl)-1,3,4-oxadiazol-2-yl)nonan-3-one (0.05 mmol, 1 eq), prepared as described above, was treated with a solution of (5-methoxy-2-methyl-1H-indol-3-yl)acetic acid (1.3 eq), HOBT (1.3 eq) and EDC.HCl (1.3 eq) in DMF (premixed for 3 min), followed by DIPEA (1.3 eq). The mixture was stirred at room temperature for 2 h and the product was isolated by preparative RP-HPLC, using water (+0.01% TFA) and MeCN (+0.01% TFA) as eluents (column C18). The pooled product fractions were lyophilized and the product was obtained as a white solid. MS (ES) C33H37N5O5 requires: 583.68, found: 584.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09371295B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-374a2e4418b948b7aac195e57cab520a |
| Source note | uspto-grants-2016_06 |