HRID2205697

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID84773974

未命名化合物

结构：O=C(N[C@@H](c1ccccc1)c1cccc(OCc2cccc(C(=O)O)c2)c1)O[C@H]1CN2CCC1CC2

HCID86720819

未命名化合物

结构：COC(=O)c1ccc(COc2cccc([C@@H](NC(=O)O[C@H]3CN4CCC3CC4)c3ccccc3)c2)cc1.Cl

HCID86720820

未命名化合物

PRODUCTS

生成物

结构：COC(Cc1ccc(COC(=O)c2cccc(COc3cccc([C@@H](NC(=O)O[C@H]4CN5CCC4CC5)c4ccccc4)c3)c2)cc1)OC

HCID86720818

未命名化合物

PROCEDURE

实验过程

The title compound was prepared as described in Example 1 Step 10 with (4-(2,2-dimethoxyethyl)phenyl)methanol and 3-((3-((S)-phenyl((((R)-quinuclidin-3-yloxy)carbonyl)amino)methyl)phenoxy)methyl)benzoic acid replacing 4-(2-hydroxyethoxy)-3-methylbenzaldehyde and methyl 4-((3-((S)-phenyl((((R)-quinuclidin-3-yloxy)carbonyl)amino)methyl)phenoxy)methyl)benzoate hydrochloride respectively.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e9e71a75dba64be8ab1457d1ab2f927d
来源数据集: uspto-grants-2016_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09371318B2
来源说明: uspto-grants-2016_06

反应 SMILES

[CH3:1][O:2][CH:3]([O:13][CH3:14])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][OH:12])=[CH:7][CH:6]=1.[C:15]1([C@H:21]([NH:39][C:40]([O:42][C@@H:43]2[CH:48]3[CH2:49][CH2:50][N:45]([CH2:46][CH2:47]3)[CH2:44]2)=[O:41])[C:22]2[CH:23]=[C:24]([CH:36]=[CH:37][CH:38]=2)[O:25][CH2:26][C:27]2[CH:28]=[C:29]([CH:33]=[CH:34][CH:35]=2)[C:30](O)=[O:31])[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.Cl.C1([C@H](NC(O[C@@H]2C3CCN(CC3)C2)=O)C2C=C(C=CC=2)OCC2C=CC(C(OC)=O)=CC=2)C=CC=CC=1>>[C:15]1([C@H:21]([NH:39][C:40]([O:42][C@@H:43]2[CH:48]3[CH2:49][CH2:50][N:45]([CH2:46][CH2:47]3)[CH2:44]2)=[O:41])[C:22]2[CH:23]=[C:24]([CH:36]=[CH:37][CH:38]=2)[O:25][CH2:26][C:27]2[CH:28]=[C:29]([CH:33]=[CH:34][CH:35]=2)[C:30]([O:12][CH2:11][C:8]2[CH:9]=[CH:10][C:5]([CH2:4][CH:3]([O:2][CH3:1])[O:13][CH3:14])=[CH:6][CH:7]=2)=[O:31])[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1