HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2205721Generated: October 30, 2026
Trimethylorthoacetate → 6-Bromo-3-methyl-8-nitro-[1,2,4]triazolo[4,3-a]pyridine
https://huagongshe.com/reaction/2205721
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trimethylorthoacetate | HCID 21927715 | — |
| Reactant | 5-Bromo-2-hydrazinyl-3-nitropyridine | HCID 26370200 | — |
| Product | 6-Bromo-3-methyl-8-nitro-[1,2,4]triazolo[4,3-a]pyridine | HCID 58118967 | — |
Reaction Steps
A suspension of 5-bromo-3-nitro-2-hydrazinopyridine (2.0 g, 8.58 mmol) in trimethylorthoacetate (20 mL) was heated at 80° C. for 20 h. After cooling, the solvent was distilled off, the residue was dissolved in ethyl acetate (200 mL), washed with water, brine, dried over sodium sulphate and concentrated to provide the product 6-bromo-3-methyl-8-nitro-[1,2,4]triazolo[4,3-a]pyridine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09371329B2 |
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| Source dataset | uspto-grants-2016_06 |
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| ORD ID | ord-f312f9259f004748b279a8779cb13d7e |
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| Source note | uspto-grants-2016_06 |
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