Methanesulfonic Acid → HCID 58119003, compound

Participants

Reaction Steps

To a solution of 5-(benzyloxymethyl)-6-chloro-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine, prepared as described in Step 4 (700 mg, 2.1 mmol) was added methanesulfonic acid (2 mL, 70% in water) and the reaction was heated to reflux overnight. The reaction was concentrated and the residue purified by flash chromatography to yield (6-chloro-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridin-5-yl)methanol.

Provenance & Evidence