HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 178474492, compound → 4-(2-phenylethynyl)-3-(trifluoromethyl)-1H-pyrazol-5-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 178474492 | HCID 178474492 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | 4-(2-phenylethynyl)-3-(trifluoromethyl)-1H-pyrazol-5-amine | HCID 178509122 | — |
Reaction Steps
A solution of N-[4-(2-phenylethynyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]acetamide (900 mg, 3.07 mmol) in ethanol (12 mL) and 25% NaOH (9 mL) was heated to 70° C. for 1.5 h. The organic layer was separated and the aqueous extracted with EtOAc (×2).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09371332B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-2741886eac964a27b80037250bd38512 |
| Source note | uspto-grants-2016_06 |