Water → 4-(1-Ethyl-5-methyl-1H-pyrazol-4-ylmethyl)-3'-(4-methoxymethyl-phenyl)-3,4,5,6-tetrahydro-2H-[1,2']bipyrazinyl hydrochloride

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Reaction Steps

Combine 3′-chloro-4-(1-ethyl-5-methyl-1H-pyrazol-4-ylmethyl)-3,4,5,6-tetrahydro-2H-[1,2′]bipyrazinyl (0.300 g, 0.935 mmol), potassium carbonate (0.310 g, 2.24 mmol), 4-methoxymethylphenylboronic acid (0.186 g, 1.12 mmol), and tetrakis(triphenylphosphine)palladium(0) (0.011 g, 0.009 mmol) in N,N-dimethylacetamide (1.9 mL). Add water (940 μL), and reflux reaction for 6 hr. Add DCM and wash with water. Extract water layer three times with DCM. Dry combined organics (magnesium sulfate) and purify (silica gel chromatography, eluting with 50:50 to 100:0 ethyl acetate:hexanes then 10:90 to 20:80 methanol:ethyl acetate), to give the free base of the title compound (256 mg, 67%). Dissolve the free base (0.254 g, 0.624 mmol) in acetonitrile (748 μL) and add aq. 1 N HCl solution (748 μL, 0.748 mmol). Shake for 15 min. at ambient temperature. Freeze dry to give the title compound (273 mg, 99%). MS (ES): m/z=407 [M+H]+.

Provenance & Evidence